Biology

Grants classified within the biology field of interest focus on understanding the development, progression, and metastasis (spread) of pancreatic cancer. According to the National Cancer Institute’s Common Scientific Outline, these projects deal with one or more of the following research topics: (1) normal functioning; (2) cancer initiation: alterations in chromosomes; (3) cancer initiation: oncogenes and tumor suppressor genes; (4) cancer progression and metastasis; and (5) resources and infrastructure related to cancer biology. Click below to learn about these grants.

2009 Seena Magowitz – Pancreatic Cancer Action Network - AACR Pilot Grant
George A. Calin, MD, PhD
MD Anderson Cancer Center
Roles of MicroRNAs and Ultraconserved Genes in Pancreatic Cancers

2006 Pancreatic Cancer Action Network – AACR Career Development Award
Ru Chen, PhD
University of Washington
Identifying the Role of the Notch Signaling Pathway in the Development of Pancreatic Ductal Adenocarcinoma

2003 Samuel Stroum – Pancreatic Cancer Action Network – ASCO Young Investigator Award
Christopher Cogle, MD
University of Florida
Defining the Hemangioblast in Tumor Neoangiogenesis

2008 Seena Magowitz – Pancreatic Cancer Action Network – AACR Career Development Award
David Dawson, MD, PhD
University of California, Los Angeles
Wnt Signaling in Pancreatic Cancer Progenitor Cells

2007 Carole and Bob Daly – Pancreatic Cancer Action Network – AACR Career Development Award
Martin E. Fernandez-Zapico, MD
Mayo Clinic, Rochester
Characterization of the Hedgehog Interacting Pathways in Pancreatic Cancer

2009 Ruth Fredman Cernea – Pancreatic Cancer Action Network – AACR Fellowship
Philippe Foubert, PhD
University of California, San Diego
Role of Inflammation in Pancreatic Cancer

2009 Pancreatic Cancer Action Network – AACR Pilot Grant
Qingshen Gao, MD
NorthShore University HealthSystem Research Institute
Discovery of Novel Pancreatic Cancer Susceptibility Genes

2007 Nancy Daly Riordan – Pancreatic Cancer Action Network – AACR Career Development Award
Paul J. Grippo, PhD
Northwestern University
Evaluating Kras Oncogene Addiction in Pancreatic Precancer and Cancer

2008 Michael C. Sandler – Pancreatic Cancer Action Network – AACR Pilot Grant
Matthias Hebrok, PhD
University of California, San Francisco
NF-kB Signaling in PanIN Formation

2005 Dr. Laurence A. Mack and Roselle Mack Memorial – Pancreatic Cancer Action Network – AACR Career Development Award
Sunil R. Hingorani, MD, PhD
Fred Hutchinson Cancer Research Center
The Cell-of-Origin in Pancreatic Cancer

2009 Samuel Stroum – Pancreatic Cancer Action Network – AACR Fellowship
Eric Humke, MD, PhD
Stanford University
A Novel Paracrine Hedgehog Signaling Loop in Pancreatic Adenocarcinoma

2007 Pancreatic Cancer Action Network Pilot Grant
Christine Iacobuzio-Donahue, MD, PhD
Johns Hopkins University
Using a Genomic Scale to Identify the Genes that Play a Role in the Ability of Pancreatic Cancer to Metastasize to Other Organs

2005 Pancreatic Cancer Action Network – AACR Career Development Award
Mircea Ivan, MD, PhD
Tufts University School of Medicine
Exploring Hypoxia Resistance in Pancreatic Tumors

2010 Pancreatic Cancer Action Network – AACR Career Development Award
Alec Kimmelman, MD, PhD
Dana-Farber Cancer Institute
DNA Repair and the DNA Damage Response in Pancreatic Cancer

2009 Constance Williams – Pancreatic Cancer Action Network – AACR Pilot Grant
Brian Lewis, PhD
University of Massachusetts
Involvement of miRNAs in Kras-Induced Pancreatic Tumorigenesis

2009 Larry Kwicinski – Pancreatic Cancer Action Network - AACR Career Development Award
Maxence Nachury, PhD]
Stanford University
Role of the Primary Cilium in the Initiation of Pancreatic Cancer

2009 Paul Mitchell – Pancreatic Cancer Action Network – AACR Career Development Award
Marina Pasca di Magliano, PhD
University of Michigan
Notch Signaling in Pancreatic Cancer Initiation and Progression

2010 Tempur-Pedic Retailers – Pancreatic Cancer Action Network – AACR Pathway to Leadership Grant
Zeshaan Rasheed, MD, PhD
Johns Hopkins University
Are Cancer Stem Cells Relevant in Pancreatic Adenocarcinoma?

2008 Laurie and Paul MacCaskill – Pancreatic Cancer Action Network – AACR Career Development Award
Lorenzo F. Sempere, PhD
Dartmouth Medical School
Role of MicroRNAs in Initiation and Progression of Pancreatic Cancer

2007 Ralph H. Hruban, M.D. – Pancreatic Cancer Action Network – AACR Career Development Award
Ben Stanger, MD, PhD
University of Pennsylvania
Investigation of the Pancreatic "Ductome"

2007 Pancreatic Cancer Action Network Pilot Grant
Gloria Su, PhD
Columbia University
Activin Signaling in the Development of Pancreatic Cancer Precursor Lesions

2010 Pancreatic Cancer Action Network – AACR Innovative Grant
Amy Tang, PhD
Eastern Virginia Medical School
SIAH is a Novel and Effective Anti-K-Ras Drug Target in Pancreatic Cancer

2009 Pancreatic Cancer Action Network – AACR Fellowship
David Ting, MD
Massachusetts General Hospital
Characterizing Circulating Tumor Cells in Pancreatic Cancer

2006 Samuel Stroum – Pancreatic Cancer Action Network – ASCO Young Investigator Award
Jennifer Tseng, MD
University of Massachusetts Medical School
Development of a Malignancy Prediction Rule for Cystic Lesions of the Pancreas

2003 Pancreatic Cancer Action Network – AACR Career Development Award
David Tuveson, MD, PhD
University of Pennsylvania
Tumor Suppressor Gene Loss of Heterozygosity for the Generation of a Murine Model of Ductal Pancreatic Cancer

2007 Skip Viragh – Pancreatic Cancer Action Network – AACR Career Development Award
Huamin Wang, MD, PhD
MD Anderson Cancer Center
Functional Study of Hematopoietic Progenitor Kinase-1 in Pancreatic Cancer

2006 Pancreatic Cancer Action Network – AACR Career Development Award
Daoyan Wei, PhD
MD Anderson Cancer Center
The Role of KLF4a in Pancreatic Cancer